Dual iron for constipation & fatigue

Dual iron. Dual benefits.

Most prenatal vitamins include an iron supplement to counter iron depletion.1 These vitamins, however, contain nonheme-derived iron, which frequently causes constipation.2,3

The unique combination of heme and nonheme iron in PreferaOB ONE® decreases the likelihood of patients experiencing constipation and is associated with significantly fewer gastrointestinal side effects compared to nonheme iron alone.4

Fatigue—expecting moms can expect to feel tired

During pregnancy, blood production increases dramatically to support the growing fetus, which can result in a depletion of iron stores.1,5-7 Iron-deficiency anemia can also be caused by impaired iron absorption.5

The heme and nonheme iron found in PreferaOB ONE® act together to increase overall iron absorption by 40% and help maintain patients' energy levels by stabilizing iron levels.2,5,8

What are heme and nonheme iron?

Heme and nonheme iron are dual sourced, combined to enable the body to absorb the available iron more effectively than from a single nonheme source.3

INDICATIONS AND USAGE: PreferaOB ONE® is a prescription multivitamin/multimineral nutritional supplement with Omega-3 fatty acid (life'sDHA™) indicated for use in improving the nutritional status of women throughout pregnancy and in the postnatal period for both lactating and non-lactating mothers. PreferaOB ONE® is also beneficial in improving the nutritional status of women prior to conception.


WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

CONTRAINDICATIONS: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.

WARNING: Ingestion of more than 3 grams of Omega-3 fatty acids per day has been shown to have potential antithrombotic effects, including an increased bleeding time and International Normalized Ratio (INR). Administration of Omega-3 fatty acids should be avoided in patients taking anticoagulants and in those known to have an inherited or acquired predisposition to bleeding diathesis.

PRECAUTIONS: Folic acid when administered as a single agent in doses above 0.1 mg daily may obscure pernicious anemia in that hematological remission can occur while neurological manifestations remain progressive. Pregnant women and nursing mothers should avoid supplemental doses of vitamin E higher than RDA amounts. While prescribing this nutritional supplement for pregnant women, nursing mothers, or for women prior to conception, their medical condition and other drugs, herbs, and/or supplements consumption should be considered.

ADVERSE REACTIONS: Allergic sensitization has been reported following both oral and parenteral administration of folic acid.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Full Prescribing Information.


1. Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr. 2000;71(5)(suppl): 1280S-1284S. 2. Ekman M, Reizenstein P. Comparative absorption of ferrous and heme-iron with meals in normal and iron deficient subjects. Z Emahrungswiss. 1993;32(1):67-70. 3. Seligman PA, Moore GM, Schleicher RB. Clinical studies of HIP: an oral heme-iron product. Nutr Research. 2000;20(9):1279-1286. 4. Frykman E, Bystrom M, Jansson U, Edberg A, Hansen T. Side effects of iron supplements in blood donors: superior tolerance of heme iron. J Lab Clin Med. 1994;123(4):561-564. 5. Zimmerman MB, Hurrell RF. Nutritional iron deficiency. Lancet. 2007;370(9586):511-520. 6. Scholl TO. Iron status during pregnancy: setting the stage for mother and infant. Am J Clin Nutr. 2005;81(5): 1218S-1222S. 7. Scholl TO, Hediger ML. Anemia and iron-deficiency anemia: compilation of data on pregnancy outcome. Am J Clin Nutr. 1994;59(2)(suppl):492S-501S. 8. Lee KA, Zaffke ME. Longitudinal changes in fatigue and energy during pregnancy and the postpartum period. J Obstet Gynecol Neonatal Nurs. 1999;28(2):183-191.